NFL Week 6 – Predictions & Best Bets

By Week 6, the NFL season has settled into rhythm. Contenders are separating themselves, while struggling teams face make-or-break moments. This slate features a Thursday NFC East showdown, another London game, and multiple divisional clashes with playoff implications.

From the Giants hosting the Eagles under the lights to the Chiefs in a primetime battle at Arrowhead, Week 6 delivers high-stakes matchups across the board. Injuries and shifting momentum remain critical factors, but the betting edges are beginning to sharpen as form solidifies.

Below, we break down every matchup with odds and best bets for Week 6. (Odds current as of Thursday, October 2, 2025 — lines subject to change.)

Philadelphia Eagles at New York Giants

Thursday, October 9, 8:15 p.m. ET (Prime Video)

The Eagles have been one of the most reliable teams in controlling games at the line of scrimmage. Jalen Hurts’ dual-threat ability, paired with a dominant offensive line and a disruptive defensive front, gives Philadelphia multiple ways to dictate tempo. Even if the passing attack isn’t firing on all cylinders, their run game and pass rush can take over.

The Giants, by contrast, continue to struggle with offensive rhythm. Protection issues and inconsistent quarterback play have capped their scoring, and their defense has spent too much time on the field as a result. At home they may hang around early, but against Philadelphia’s depth and physicality, sustaining four quarters is a tall task.

With Philly’s edge on both sides of the line, laying 3.5 points looks justified. If you’re betting Thursday Night Football, BetMGM’s promo is offering up to $1500 in Bonus Bets (Promo Code: NYSB1500) — giving Giants backers or Eagles bettors extra value.

Denver Broncos vs New York Jets (London, UK)

Sunday, October 12, 9:30 a.m. ET (NFL Network)

London games often hinge on preparation and which team can settle quickest. The Jets bring one of the league’s most disruptive defenses, led by Sauce Gardner in the secondary and a front seven that consistently generates pressure. That unit should travel well and keep them competitive even if the offense remains inconsistent.

Denver, meanwhile, has struggled with rhythm on both sides of the ball. Their offense has lacked efficiency when forced into long drives, and turnovers have become costly. Against a Jets defense that thrives on forcing mistakes, those problems could be magnified overseas.

In what could be a grind, the Jets’ defense gives them enough of an edge to trust them catching points in London. For Jets bettors overseas or at home, FanDuel's bonus of Bet $5 Get $300 in Bonus Bets if Your Bet Wins is not to be missed. Claim it now.

Los Angeles Rams at Baltimore Ravens

Sunday, October 12, 1:00 p.m. ET

The Rams have relied heavily on Matthew Stafford and quick-strike plays, but their protection has been shaky. Against Baltimore’s front seven, that’s a dangerous formula. The Ravens’ defense has been one of the league’s most consistent units, excelling in the red zone and limiting explosive plays.

At home, Lamar Jackson’s mobility and the Ravens’ ground game give them another path to control possession. Even in a tight contest, Baltimore’s defense and home-field advantage tilt the balance their way.

Dallas Cowboys at Carolina Panthers

Sunday, October 12, 1:00 p.m. ET

The Cowboys’ offense has been inconsistent, particularly when forced into long third downs. Injuries along the offensive line have limited Dak Prescott’s rhythm, and Dallas hasn’t been as sharp finishing drives.

Carolina, while still developing, has shown toughness at home. Their defensive front has been effective in creating pressure, and their run game gives them the ability to control tempo. In a game likely to be close, the Panthers’ physical style and home crowd give them underdog value.

Arizona Cardinals at Indianapolis Colts

Sunday, October 12, 1:00 p.m. ET

The Cardinals have been competitive but still lean heavily on big plays, and their defense has struggled to contain efficient passing attacks. That inconsistency has kept them from closing out winnable games.

Indianapolis, meanwhile, has found a steadier rhythm at home. Their rookie quarterback has shown growth each week, especially when supported by Jonathan Taylor and a strong offensive line. Against Arizona’s secondary, Indy should be able to sustain drives and control tempo.

At a field goal, the Colts’ balance and more reliable quarterback play make them the side to back.

Seattle Seahawks at Jacksonville Jaguars

Sunday, October 12, 1:00 p.m. ET

Jacksonville’s offense has looked more cohesive each week, with Trevor Lawrence distributing the ball efficiently and the run game providing balance. Their ability to sustain drives makes them difficult to put away, especially at home.

Seattle has been streaky, alternating strong halves with costly breakdowns. Protection for Geno Smith remains a concern, and against Jacksonville’s improving front, mistakes could snowball.

The Jaguars’ consistency and home-field edge make them the stronger side to back.

Los Angeles Chargers at Miami Dolphins

Sunday, October 12, 1:00 p.m. ET

This matchup brings shootout potential. Justin Herbert and the Chargers can score in bunches when their protection holds, while Miami’s speed with Tyreek Hill sidelined still allows them to stretch defenses vertically and create mismatches with Jaylen Waddle and the backfield.

Neither defense has been particularly reliable against big plays, and both teams are comfortable pushing tempo. With playmakers on both sidelines, the over is the best angle in Miami.

Cleveland Browns at Pittsburgh Steelers

Sunday, October 12, 1:00 p.m. ET (CBS)

Cleveland has turned to a rookie quarterback, and while there have been flashes of promise, the offense remains inconsistent. Protection issues and turnovers have limited their ceiling, putting too much pressure on the defense to carry games.

The Steelers thrive in exactly this type of matchup. T.J. Watt and the Pittsburgh front can disrupt inexperienced quarterbacks, and at home, their defense typically sets the tone. Even if the Steelers’ own offense isn’t explosive, their ability to win field position battles and force mistakes makes the difference.

With the matchup tilted heavily toward Pittsburgh’s pass rush, laying four points looks like the right side.

Tennessee Titans at Las Vegas Raiders

Sunday, October 12, 4:05 p.m. ET

Both teams lean on their ground games but have been vulnerable defensively. The Titans continue to give up chunk plays through the air, while the Raiders’ secondary has struggled to contain even average passing attacks.

With both quarterbacks capable of taking advantage of mistakes and neither defense fully trustworthy, this matchup has sneaky shootout potential. The total in the mid-40s feels reachable, making the over the sharper side.

New England Patriots at New Orleans Saints

Sunday, October 12, 4:25 p.m. ET

The Patriots remain competitive defensively but have been unable to generate much on offense. Their quarterback play has been erratic, and they’ve struggled in the red zone, settling for field goals far too often.

New Orleans, though not explosive, has been steadier in protecting the football and capitalizing on opponents’ mistakes. At home, their defensive front has the ability to frustrate New England’s attack, and with a modest line, the Saints’ consistency gives them the edge.

San Francisco 49ers at Tampa Bay Buccaneers

Sunday, October 12, 4:25 p.m. ET

The 49ers remain one of the most balanced teams in the NFL, with Christian McCaffrey anchoring the ground game and Brock Purdy playing efficiently behind strong protection. Defensively, even with some injuries, San Francisco’s front seven continues to control games.

Tampa has struggled to find offensive consistency, often leaning on big plays to stay alive. Against the disciplined 49ers defense, that’s a risky path. San Francisco’s depth and ability to win in the trenches give them the edge on the road.

Cincinnati Bengals at Green Bay Packers

Monday, October 13, 8:15 p.m. ET (MNF)

Green Bay has looked composed under Jordan Love, with a young receiving corps continuing to build chemistry and a defense that has held up in key moments. At Lambeau, their balance and ability to win in the trenches should give them an edge.

The Bengals, still without a healthy Joe Burrow, have lacked consistency on offense. While they remain dangerous with Ja’Marr Chase and Tee Higgins, production has dipped without Burrow’s timing and accuracy. Playing on the road against a disciplined defense only compounds those struggles.

In a tight line, Green Bay’s steadiness and home-field advantage make them the side to back under the lights.

Detroit Lions at Kansas City Chiefs

Sunday, October 12, 8:20 p.m. ET (NBC)

Sunday Night Football delivers one of the marquee matchups of the week as the Lions travel to Arrowhead to face Patrick Mahomes and the Chiefs. Kansas City has not been as explosive at times this season, but Mahomes still thrives in primetime, and Travis Kelce continues to be the go-to playmaker in big moments. The Chiefs’ defense has shown progress against the run, though stopping Detroit’s versatile ground game will be a tall order.

The Lions enter with one of the NFL’s most balanced attacks. Jared Goff has been protected well by a top-tier offensive line, giving him time to distribute to Amon-Ra St. Brown and his supporting cast. The running back duo provides both power and explosiveness, making Detroit difficult to contain for four quarters. Defensively, however, the Lions have shown vulnerability against elite quarterbacks, which Mahomes is well-positioned to exploit.

With two high-powered offenses and playmakers on both sidelines, this matchup sets up for points. Kansas City’s ability to score quickly combined with Detroit’s efficiency in sustaining drives suggests long stretches of trading touchdowns. At 51, the total is high, but the over looks like the sharper play in a primetime setting where both offenses are capable of pushing the pace.

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Buffalo Bills at Atlanta Falcons

Monday, October 13, 7:15 p.m. ET (MNF)

The Bills continue to look like one of the AFC’s most complete teams, with Josh Allen leading an offense that can strike both through the air and on the ground. Their defense has been opportunistic, generating pressure and turnovers that flip momentum.

Atlanta, meanwhile, has struggled to sustain drives, relying heavily on Bijan Robinson and an inconsistent passing game. Against a Buffalo defense built to shut down one-dimensional attacks, those limitations become harder to mask. With more ways to win on both sides of the ball, the Bills are the side to back in primetime.

Chicago Bears at Washington Commanders

Monday, October 13, 8:15 p.m. ET (MNF)

The Commanders have found rhythm behind Jayden Daniels, with a balanced offense complementing a disruptive front seven. At home, their ability to generate pressure and win on early downs makes them difficult to play against.

Chicago continues to struggle with protection and consistency, leaving their quarterback under constant duress. While the Bears’ defense can compete, it often spends too much time on the field due to stalled drives. Washington’s stability and defensive edge give them the advantage under the lights.

Week 6 Betting Takeaways

By Week 6, early-season trends have started to solidify, and the market is adjusting quickly. Teams like the Bills, 49ers, and Ravens have proven dependable, while others such as the Bears and Giants continue to battle major offensive issues. Quarterback injuries remain a storyline, with matchups like Packers–Bengals and Jets–Broncos shaped heavily by who is — or isn’t — under center.

Totals stand out again this week. The Lions–Chiefs primetime clash points to fireworks, while AFC North battles like Browns–Steelers project as more defensive, grind-it-out affairs. The London game adds volatility, with the Jets’ defense capable of keeping things close but questions lingering around their quarterback play.

Primetime always draws attention, and this week’s national spots — Lions–Chiefs on Sunday night and the Bills–Falcons / Bears–Commanders Monday doubleheader — highlight different types of value. Overs may be inflated in shootout environments, while underdogs with defensive edges, like the Jets, can offer contrarian appeal.

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